Acceptance, efficacy, and safety of COVID-19 vaccination in older patients with cancer.

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  • Deprecated function : Creation of dynamic property SelectQuery::$alterTags is deprecated dans SelectQuery->addTag() (ligne 978 dans /home/gerontopcx/www/includes/database/select.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property SelectQuery::$alterMetaData is deprecated dans SelectQuery->addMetaData() (ligne 997 dans /home/gerontopcx/www/includes/database/select.inc).
  • Deprecated function : Creation of dynamic property SelectQuery::$alterTags is deprecated dans SelectQuery->addTag() (ligne 978 dans /home/gerontopcx/www/includes/database/select.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property SelectQuery::$alterTags is deprecated dans SelectQuery->addTag() (ligne 978 dans /home/gerontopcx/www/includes/database/select.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property SelectQuery::$alterTags is deprecated dans SelectQuery->addTag() (ligne 978 dans /home/gerontopcx/www/includes/database/select.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property SelectQuery::$alterTags is deprecated dans SelectQuery->addTag() (ligne 978 dans /home/gerontopcx/www/includes/database/select.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property SelectQuery::$alterTags is deprecated dans SelectQuery->addTag() (ligne 978 dans /home/gerontopcx/www/includes/database/select.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property SelectQuery::$alterTags is deprecated dans SelectQuery->addTag() (ligne 978 dans /home/gerontopcx/www/includes/database/select.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
TitreAcceptance, efficacy, and safety of COVID-19 vaccination in older patients with cancer.
Publication TypeJournal Article
Year of Publication2022
AuthorsCouderc A-L, Ninove L, Nouguerède E, Rey D, Rebroin M, Daumas A, Tomasini P, Greillier L, Salas S, Duffaud F, Dahan L, Duluc M, Garcia M-E, Pluvy J, Chaléat S, Farnault L, Venton G, Fourié T, Nurtop E, de Lamballerie X, Villani P, Charrel R, Correard F
JournalJ Geriatr Oncol
Volume13
Issue6
Pagination850-855
Date Published2022 07
ISSN1879-4076
Mots-clésAged, Aged, 80 and over, BNT162 Vaccine, COVID-19, COVID-19 Vaccines, Female, Humans, Male, Neoplasms, Vaccination, Vaccines
Résumé

PURPOSE: The COVID-19 vaccination campaign began in December 2020, in France, and primarily targeted the oldest people. Our study aimed to determine the level of acceptance of vaccination in a population of older patients with cancer.METHODS: From January 2021, we offered vaccination with the BNT162b2 COVID-19 vaccine to all patients 70 years and older referred to our geriatric oncology center in Marseille University Hospital (AP-HM) for geriatric assessment before initiation of an oncological treatment. Objectives were to evaluate acceptance rate of COVID-19 vaccination and to assess vaccine safety, reactogenicity, and efficacy two months after the first dose.RESULTS: Between January 18, 2021 and May 7, 2021, 150 older patients with cancer were offered vaccination after a geriatric assessment. The majority were men (61.3%), with a mean age of 81 years. The two most frequent primary tumors were digestive (29.4%) and thoracic (18%). The vaccine acceptance rate was 82.6% and the complete vaccination rate (2 doses) reached 75.3%. Among the vaccinated patients, 15.9% reported mild side effects after the first dose and 23.4% after the second dose, mostly arm pain and fatigue. COVID-19 cases were observed in 5.1% of vaccinated patients compared with 16.7% in unvaccinated patients. Of the 22 vaccinated patients who agreed to have their serum tested, 15 had antibodies against the spike protein at day 21 after the first dose.CONCLUSION: Our study showed a high acceptance rate of COVID-19 vaccination, with good tolerance in this frail population. These results highlight the benefits of organizing vaccination campaigns at the very beginning of oncological management in older patients.CLINICAL TRIAL REGISTRATION: This study was registered May 23, 2019 in ClinicalTrials.gov (NCT03960593).

DOI10.1016/j.jgo.2022.05.002
Alternate JournalJ Geriatr Oncol
PubMed ID35589542
PubMed Central IDPMC9108027

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