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Clinical relevance of brain atrophy subtypes categorization in memory clinics.

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  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property SelectQuery::$alterMetaData is deprecated dans SelectQuery->addMetaData() (ligne 997 dans /home/gerontopcx/www/includes/database/select.inc).
  • Deprecated function : Creation of dynamic property SelectQuery::$alterTags is deprecated dans SelectQuery->addTag() (ligne 978 dans /home/gerontopcx/www/includes/database/select.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property SelectQuery::$alterTags is deprecated dans SelectQuery->addTag() (ligne 978 dans /home/gerontopcx/www/includes/database/select.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property SelectQuery::$alterTags is deprecated dans SelectQuery->addTag() (ligne 978 dans /home/gerontopcx/www/includes/database/select.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property SelectQuery::$alterTags is deprecated dans SelectQuery->addTag() (ligne 978 dans /home/gerontopcx/www/includes/database/select.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property SelectQuery::$alterTags is deprecated dans SelectQuery->addTag() (ligne 978 dans /home/gerontopcx/www/includes/database/select.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property SelectQuery::$alterTags is deprecated dans SelectQuery->addTag() (ligne 978 dans /home/gerontopcx/www/includes/database/select.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
  • Deprecated function : Creation of dynamic property DatabaseCondition::$stringVersion is deprecated dans DatabaseCondition->compile() (ligne 1887 dans /home/gerontopcx/www/includes/database/query.inc).
TitreClinical relevance of brain atrophy subtypes categorization in memory clinics.
Publication TypeJournal Article
Year of Publication2021
AuthorsPlanche V, Bouteloup V, Mangin J-F, Dubois B, Delrieu J, Pasquier F, Blanc F, Paquet C, Hanon O, Gabelle A, Ceccaldi M, Annweiler C, Krolak-Salmon P, Habert M-O, Fischer C, Chupin M, Béjot Y, Godefroy O, Wallon D, Sauvee M, Bourdel-Marchasson I, Jalenques I, Tison F, Chêne G, Dufouil C
Corporate Authorsthe MEMENTO Study group.
JournalAlzheimers Dement
Volume17
Issue4
Pagination641-652
Date Published2021 04
ISSN1552-5279
Mots-clésAged, Alzheimer Disease, Ambulatory Care Facilities, Atrophy, Brain, Cohort Studies, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Memory Disorders
Résumé

INTRODUCTION: The clinical relevance of brain atrophy subtypes categorization in non-demented persons without a priori knowledge regarding their amyloid status or clinical presentation is unknown.METHODS: A total of 2083 outpatients with either subjective cognitive complaint or mild cognitive impairment at study entry were followed during 4 years (MEMENTO cohort). Atrophy subtypes were defined using baseline magnetic resonance imaging (MRI) and previously described algorithms.RESULTS: Typical/diffuse atrophy was associated with faster cognitive decline and the highest risk of developing dementia and Alzheimer's disease (AD) over time, both in the whole analytic sample and in amyloid-positive participants. Hippocampal-sparing and limbic-predominant atrophy were also associated with incident dementia, with faster cognitive decline in the limbic predominant atrophy group. Lewy body dementia was more frequent in the hippocampal-sparing and minimal/no atrophy groups.DISCUSSION: Atrophy subtypes categorization predicted different subsequent patterns of cognitive decline and rates of conversion to distinct etiologies of dementia in persons attending memory clinics.
DOI10.1002/alz.12231
Alternate JournalAlzheimers Dement
PubMed ID33325121